The 1980s and 1990s have witnessed a worldwide epidemic of heroin addiction and countries around the world have moved to put in place opiate replacement therapy programs to deal with this problem while most of these programs use methadone as a substitute drug of choice most recently buprenorphine laam levo acetyl methadol and heroin have been employed for this purposea comprehensive . Abstract background methadone maintenance was the first widely used opioid replacement therapy to treat heroin dependence and it remains the best researched treatment for this problem despite the widespread use of methadone in maintenance treatment for opioid dependence in many countries it is a controversial treatment whose effectiveness has been disputed. Methadone maintenance treatment mmt a form of opioid replacement therapy reduces and or eliminates the use of illegal opiates the criminality associated with opiate use and allows patients to improve their health and social productivity methadone is an agonist of opioids if initial doses during the beginning of treatment are too high or are concurrent with illicit opioid use this may . Methadone maintenance treatment and other opioid replacement therapies jeff ward richard p mattick wayne hall on amazoncom free shipping on qualifying offers a comprehensive guide to the use of drug substitution in the treatment of opiate dependence this handbook provides an up to date account of treatment research and practice in this growing area. A methadone a substance categorized as an opioid is used as a replacement drug in the medical treatment of opioids addiction compared to other opioids such as heroin morphine and codeine methadone is longer acting 24 72 hours and can be administered once a day to prevent the withdrawal symptoms during detoxification of other opioids
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