Oxidative stress and free radical generation catalyzed by redox metals have been shown to play pivotal role in regulating redox reactions in vivo contributing rns and ros main culprits in neurodegeneration while considering role of oxidative stress in neurodegeneration few important aspects need to be mentioned in brief are. 3 oxidative stress in neurodegeneration one of the most metabolically active organs of the body is the brain including the spinal cord comprising central nervous system cns which even at rest utilizes an estimated 20 of the total oxygen uptake. It has been demonstrated that oxidative stress has a ubiquitous role in neurodegenerative diseases major source of oxidative stress due to reactive oxygen species ros is related to mitochondria as an endogenous source although there is ample evidence from tissues of patients with neurodegenerative disorders of morphological biochemical and molecular abnormalities in mitochondria it is . Oxidative stress is a well studied early response in chronic neurodegenerative diseases including alzheimers disease where neuronal loss can exceed 90 in the vulnerable neuronal population. Oxidative stress and age related neurodegeneration oxidative stress and disease 2005 11 21 unknown books amazonca skip to main content try prime books go search en hello sign in your account sign in your account try prime wish list cart best
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